Current Issues of Pharmacy and Medical Sciences

Involvement of biofilm-like intracellular bacterial communities of uropathogenic Escherichia coli in pathogenesis of urinary ...

Current Issues in Pharmacy and Medical Sciences Vol. 26, No. 3, Pages 321-325

SYLWIA NOWICKA, MAGDALENA ZDZIEBŁO, MAREK JUDA, URSZULA KOSIKOWSKA, ANNA MALM

Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, Poland 

DOI: 10.12923/j.2084-980X/26.3/a.18

 

Abstract

This paper presents a precisely defined question about the role of the biofilm-like intracellular bacterial communities in pathogenesis of the urinary tract infections. According to the recent literature, uropathogenic Escherichia coli is one of the leading etiologic agents of the urinary tract infections. Although E. coli is regarded as an extracellular pathogen, some experiments have revealed a multi-step infection cycle, which involves adhesion, invasion, proliferation within invaded urothelial cell in the form of biofilm-like intracellular bacterial communities and dispersal, leading to infection of next neighbouring cells. Therefore, the prevention and treatment of the urinary tract infections must include intracellular stage of infection.

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Keywords

urinary tract infections, uropathogenic E. coli, intracellular bacterial communities

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